abstract |
The present invention relates to an imidazo [1,2-a] pyrimidone derivative represented by the formula (I), or a salt thereof, wherein X is a bond, an ethenylene group, an ethynylene group, or an optionally substituted group. An optionally substituted methylene group; a carbonyl group, an oxygen atom, a sulfur atom, a sulfonyl group, a sulfoxide group or an optionally substituted nitrogen atom, and R 1 is an optionally substituted 2, 4 or 5 -Pyrimidinyl, R2 represents a C 1-6 alkyl group, a C 1-2 perhalogenated alkyl group, a C 1-3 halogenated alkyl group, a benzyl group, a benzene ring, a naphthalene ring, 5,6,7,8 -Represents a tetrahydronaphthalene ring, a pyridine ring, an indole ring, a pyrrole ring, a thiophene ring, a furan ring or an imidazole ring, the benzyl group and these rings may be optionally substituted, and n represents 0-3 ing. The present invention relates to a medicament comprising, as an active ingredient, the derivative or a salt thereof used for the prevention and / or treatment of GSK3β such as Alzheimer's disease, or a neurodegenerative disease caused by abnormal activity of GSK3β and cdk5 / p25. Also related. [Chemical 1] |