| abstract |
Disclosed are isolated human monoclonal antibodies that bind to PSMA, and related antibody-based compositions and molecules. The human antibody can be produced in non-human transgenic animals, eg, transgenic mice capable of producing multiple isotypes of human monoclonal antibodies, by performing VDJ recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising human antibodies, non-human transgenic animals and hybridomas that produce human antibodies, and therapeutic and diagnostic methods using the human antibodies. |