| abstract |
An osmotic pharmaceutical tablet comprising a single layer compressed core surrounded by a water permeable layer having a passage is described. The monolayer core comprises (i) a non-aged drug with a solubility of less than about 1 mL −1 per dose, (ii) about 2.0% to about 20% by weight of hydroxyethylcellulose (with a weight average molecular weight of About 300,000 to about 2,000,000), and (iii) an osmotic pressure regulating substance. |