| abstract |
Pharmaceutical compositions containing urea derivatives or their salts as active ingredients are described. The pharmaceutical composition has excellent activity as a VR1 antagonist, and prevention and treatment of diseases associated with VR1 activity, particularly urge urinary incontinence, excessive contraction of the bladder, chronic pain, neuropathic pain, postoperative Useful for the treatment of pain, rheumatoid arthritis, neuralgia, nerve injury, hyperalgesia, nerve trauma, ischemia, neurodegeneration, stroke, ataxia, and / or inflammatory diseases. |