| abstract |
The present invention provides the following structural formula (I): [Chemical 1] [Wherein (A) R1 is hydrogen, and C 1 -C 8 alkyl, aryl -C 0-4 - alkyl, heteroaryl -C 0-4 - alkyl, C3-C6 cycloalkyl aryl -C 0-2 - alkyl and - CH 2 -C (O) -R17- R18 is selected from the group consisting of substituted or unsubstituted groups selected from (here, R17 is O or NH, and R18 is also benzyl which is optionally substituted); (B) R2 is, C 1 -C 6 alkyl, C 1 -C 6 alkenyl, aryl -C 0-4 - alkyl, heteroaryl -C 0-4 - alkyl, C 1 -C 4 alkyl sulfonamide, C 1 -C 4 alkyl amide is selected from the group consisting of OR10 and C 3 -C 6 cycloalkyl; (C) W is O or S; (D) X is also C 1 -C 5 alkylene linker that be substituted, here, one carbon atom of the linker O, NH, may be replaced by S, the two carbon Together they may form a double bond; (E) Y is, C, O, S, is selected from NH and the group consisting of a single bond; selection and (f) E is, C (R3) (R4) A, A, and from (CH 2) n COOR19 Selected from the group consisting of substituted or unsubstituted groups. |