| abstract |
The present invention comprises the following components: I) a direct or indirect, antiproliferative or cytotoxically active expression product or a nucleotide sequence encoding a plurality of said expression products, II) constitutively active Or a nucleotide sequence encoding a plasma protein under the control of an activation sequence, or III) optionally an activation sequence that is optionally constitutively active or can be activated in a microorganism A nucleotide sequence encoding a cell-specific ligand under the control of IV, IV) inducing the expression of the expression products of components I) and II) and optionally III) on the outer surface of the microorganism, or the expression of component I) A nucleotide sequence for a transport system that induces product secretion and expression of components II) and optionally III) and is preferably constitutively active; V) optionally mammalian cells Nucleotide sequences for proteins used for the lysis of microorganisms in the cytosol and for the intracellular release of plasmids having at least one or more components I) and VI) contained in the lysed microorganisms; and VI) An activation sequence that can be activated in a microorganism and / or is tissue cell specific, tumor cell specific, function specific or non-cell specific to express component I): The present invention relates to a microorganism having a coating that can be inserted into and expressed. The microorganism of the present invention is further characterized in that any of the above components I) to VI) is present once or several times and can be the same or different. |