| abstract |
The use of nanoparticles of inorganic materials (eg, synthetic smectite clays) in ophthalmic and otic pharmaceutical compositions is described. The nanoparticles are utilized to modify the rheological properties of the composition to improve the viscosity, flow properties, lubricity or other properties of the composition. In particular, the present invention relates to the provision of ophthalmic and otic lubricious compositions and the improvement of artificial tear viscosity, shear thinning and lubricity. The figure shown demonstrates the change in the physical properties of the composition. |