| abstract |
Formula The compound represented by provides a (pharmacological) agent that is a potent agonist of the peroxisome proliferator activated receptor (PPAR). Accordingly, the compounds of the present invention are useful for the treatment of conditions mediated by PPAR receptor activity in mammals. The above conditions include abnormal lipid metabolism, hyperlipidemia, hypercholesterolemia, atherosclerosis, hypertriglyceridemia, heart failure, myocardial infarction, vascular disease, cardiovascular disease, hypertension, obesity, inflammation, arthritis Cancer, Alzheimer's disease, skin disease, respiratory disease, ophthalmic disease, irritable bowel disease, ulcerative colitis and Crohn's disease. The compounds of the present invention are particularly useful in mammals as hypoglycemic agents for the treatment and prevention of conditions involving impaired glucose tolerance, hyperglycemia and insulin resistance such as type 1 and type 2 diabetes and syndrome X. Preferred are compounds of the invention which are dual agonists of PPARĪ± and PPARĪ³ receptors. |