| abstract |
The present invention provides a compound of formula R 1 -OAOR 2 wherein A is a C 2-10 alkylene group, R 1 is independently a first hydroxy protecting group (eg, an ester group), and R 2 is independently -H or a second hydroxy protecting group (eg an ester group). Certain alkanediol derivatives, and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof, particularly osteoclast survival, It relates to those that inhibit formation and / or activity and / or inhibit bone resorption. The present invention also includes pharmaceutical compositions containing such compounds, for inhibiting osteoclast survival, formation and / or activity both in vitro and in vivo, and mediated by osteoclasts, and / or Such compounds and compositions for inhibiting conditions such as osteoporosis, rheumatoid arthritis, cancer-related bone disease, Paget's disease, and / or conditions associated with inflammation or immune system activation, characterized by bone resorption Use of things. |