| abstract |
Formula (I) [wherein m is 0-4, R 1 is C 1-6 alkyl, C 3-7 cycloalkyl, C 2-6 alkenyl, —SO 2 NR 4 R 5 , —CONR Selected from 4 R 5 and —COOR 4 ; when m is 2-4, R 1 is further C 1-6 alkoxy, hydroxy, NR 4 R 5 , —NR 4 SO 2 R 5 , —NR 4 Also selected from SOR 5 , —NR 4 COR 5 and —NR 4 CONR 4 R 5 ; R 2 is selected from hydrogen, C 1-6 alkyl and — (CH 2 ) n —C 3-7 cycloalkyl; R 3 is a group —CO—NH— (CH 2 ) p —R 6 ; U is selected from methyl and halogen; W is selected from methyl and chlorine; V and Y are each hydrogen, Independently selected from methyl and halogen; m is selected from 0, 1, 2, 3 and 4, wherein each carbon atom of the resulting carbon chain is optionally independent of C 1-6 alkyl Optionally selected from 1 or 2 groups; n is selected from 0, 1, 2 and 3; P and r are independently selected from 0, 1 and 2; s is selected from 0, 1 and 2] or a pharmaceutically acceptable salt or solvate thereof; And their use as pharmaceuticals, in particular as p38 kinase inhibitors. [Chemical 1] |