| abstract |
Isolated nucleic acid molecules encoding T-bet and isolated T-bet polypeptides are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vector has been introduced, and non-human transgenic animals carrying a T-bet transgene. The present invention further provides T-bet fusion proteins and anti-T-bet antibodies. Methods for detecting T-bet expression and / or activity in a biological sample, methods for modulating T-bet expression and / or activity in a cell, and agents that modulate T-bet expression and / or activity Also disclosed are methods of using the T-bet compositions of the present invention, including methods of identification. |