abstract |
Compounds selected from compounds of formula (I) below and optionally addition salts thereof with optical isomers, N-oxides and pharmaceutically acceptable acids or bases, and specific inhibition of matrix metalloprotease type 13 comprising said Pharmaceutical products useful as agents are: [Chemical 1] [Wherein W 1 represents O, S or —NR 3 (wherein R 3 represents hydrogen, alkyl, OH or CN), and W 2 represents hydrogen, CF 3 , NH 2 , monoalkylamino, dialkylamino. Represents a group selected from: alkyl, alkenyl, aryl, arylalkyl, cycloalkyl, heterocyclic, wherein said groups are optionally substituted, or W 1 and W 2 together are of the formula —N═X 4 -W 3- (as defined herein), X 1 , X 2 and X 3 represent optionally substituted N or C, n is 0-8, Z represents —CR 12 R 13 (R 12 and R 13 are as defined herein), A represents a ring system, and the group R 2 is hydrogen or as defined herein. Represents various chemical groups, q is 0-7, R 1 is hydrogen, alkyl, Represents lukenyl, alkynyl or a ring system]. |