| abstract |
The present invention relates to compositions and methods for identifying one or more second drug targets and their use in identifying a drug or drug candidate, particularly for the treatment of cancer or cell replication disorders. Synthetic lethal screening based on yeast is used to functionally identify and confirm new gene targets for killing cells that are defective in the cell cycle pathway. These newly identified gene targets can be used to develop new therapies to treat cancer, benign cell proliferation, and yeast infections. |