abstract |
The present invention has the formula: [Chemical 1] [Wherein the variables in the formula are as defined in the present specification] The compound shown by is disclosed. The compounds of the present invention are non-peptide reversible inhibitors of type 2 methionine aminopeptidase. The present invention also provides such compounds in the treatment of conditions mediated by angiogenesis such as cancer, hemangiomas, proliferative retinopathy, rheumatoid arthritis, atherosclerotic neovascularization, psoriasis, ocular neovascularization and obesity. Disclose the use of. |