abstract |
A hydroxyeicosenoic acid analog represented by the following formula (I), or a pharmaceutically acceptable salt or hydrate thereof: [Chemical 1] (Where Bonding Represents a cisvinylene group or an ethynylene group; Y represents CH 2 , O or S (O) p , where p is 0, 1 or 2; m represents an integer of 1 to 4, n represents an integer of 0 to 3, and the sum of m and n is an integer of 3 to 7; R 1 represents a C 1-4 alkyl group or a C 3-8 cycloalkyl group; R 2 represents a hydrogen atom or a methyl group; R 3 represents COR 4 , a nitrile group, a halogen atom, a tetrazole group or a thiazolidinedione group; R 4 represents OR 6 , NHR 6 , N (OH) R 6 , NHSO 2 R 5 , glycerol or functional glycerol; R 5 represents a C 1-15 alkyl group, a C 6-10 aryl group, or a C 7-14 aryl group substituted with an alkyl group, a halogen or an amino group; R 6 represents a C 1-10 alkyl group substituted with a hydrogen atom, C 1-10 alkyl group or a hydroxyl group). The compounds of the present invention are useful as elastase release inhibitors. |