| abstract |
Compounds of general formula I: R 1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl and pyridine N-oxide; R 2 is independently from ethyl and isopropyl R 3 is independently selected from hydrogen and fluoro; R 4 is independently selected from —OH, —NH 2 and —NHSO 2 R 5 ; and R 5 is independently hydrogen, selected from -CF 3 and C 1 -C 6 alkyl, or a salt thereof or separate enantiomers and salts thereof; case, R 1 heteroaromatic ring may optionally each independently a straight-chain and branched C 1 -C 6 alkyl, NO 2, CF 3, C 1 -C 6 alkoxy, chloro, fluoro, bromo, and may be further substituted by 1, 2 or 3 substituents selected from iodo, The substitution on the heteroaromatic ring can be carried out at any position on the ring system; and the pharmaceutical compositions and treatments, particularly pain, comprising the individual enantiomers and salts of the compounds and the new compounds Its use in the treatment of anxiety and functional gastrointestinal disorders is disclosed and claimed herein. |