| abstract |
The present invention provides a water-soluble polymer conjugate of retinoic acid. The conjugates of the invention are prepared by covalently coupling a water-soluble non-peptidic polymer such as polyethylene glycol to a retinoid such as retinoic acid. The polymer portion of the conjugate can be linear (ie, prepared using end-capped PEG or methoxy PEG, or is a linear bifunctional PEG), or It can be branched or forked. The conjugates of the present invention are water-soluble and are particularly useful in the treatment by inhalation of airway conditions that are responsive to retinoid therapy. |