| abstract |
Formula (I): [Chemical 1] [Where: R 1 is an optionally substituted phenyl group; R 2 is selected from hydrogen, C 1-6 alkyl and — (CH 2 ) p —C 3-7 cycloalkyl; R 3 is [Chemical formula 2] A group of formula (II); R 4 is selected from hydrogen and C 1-4 alkyl; U is selected from methyl and halogen; X and Y are independently selected from hydrogen, methyl and halogen; m is 0, 1, 2, 3 and 4, optionally substituted with up to 2 groups independently selected from C 1-6 alkyl; n is selected from 0, 1 and 2; p is selected from 0, 1 and 2] Or their pharmaceutically acceptable salts or solvates, and their use as pharmaceuticals, particularly p38 kinase inhibitors. |