| abstract |
The present invention relates to a compound of formula (I) [Chemical 1] [Where: Ring A represents a 6-membered heterocyclic ring, R 1 is hydrogen; aryl; formyl; C 1-6 alkylcarbonyl; optionally substituted C 1-6 alkyl; C 1-6 alkyloxycarbonyl; C 1-6 alkyloxy optionally substituted by C 1-6 alkylcarbonyl, X is a direct bond or a linker atom or group, Z is O or S, R 2 is hydrogen, C 1- 10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, carbocycle or heterocycle, wherein said groups are each optionally substituted, R 3 is hydrogen; hydroxy; halo; C 1-6 alkyl or C 2-6 alkenyl or C 2-6 alkynyl optionally substituted by: C 1-6 alkyloxy; C 1-6 alkylthio; C 1-6 alkyloxycarbonyl; C 1-6 alkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or di (C 1-6 alkyl) amino; polyhaloC 1-6 alkyl; polyhaloC 1-6 alkyl oxy; polyhaloC C 1-6 alkylthio; R 21; R 21 -C 1-6 alkyl; R 21 -O-; R 21 -S- ; R 21 -C (= O) -; R 21 -S (= O P −; R 7 —S (═O) p —; R 7 —S (═O) p —NH—; R 21 —S (═O) p —NH—; R 7 —C (═O) — ; -NHC (= O) H; -C (= O) NHNH 2; R 7 -C (= O) -NH-; R 21 -C (= O) -NH -; - C (= NH) R 7 -C (= NH) R 21 , wherein R 4a or R 4b are each independently hydrogen, R 8 , —Y 1 —NR 9 —Y 2 —NR 10 R 11 , —Y 1 —NR 9 —Y 1 —R 8 , —Y 1 —NR 9 R 10 , provided that —X—R 2 and / or Or subject to R 3 being other than hydrogen], N-oxides thereof, pharmaceutically acceptable addition salts, quaternary amines and stereochemically isomeric forms thereof; The present invention relates to a pharmaceutical composition containing these and a method for producing them. |