abstract |
The present invention provides a polymer conjugate of an opioid antagonist, which contains a polymer (eg, poly (ethylene glycol)) covalently attached to the opioid antagonist. The linkage between the polymer and the opioid antagonist is preferably hydrolytically stable. The present invention also includes a method of treating one or more side effects (eg, constipation, nausea or pruritus) associated with the use of an opioid antagonist by administering a polymer conjugate of the present invention. |