| abstract |
NMDA receptor blockers (including pH sensitive NMDA receptor blockers) are provided as neuroprotective drugs, which are used in seizures, traumatic brain injury, epilepsy, and other neurological events involving the acidification of brain or spinal tissue. Useful. The compositions and methods of the present invention are used to treat neurodegeneration resulting from NMDA receptor activation. The compounds described herein have enhanced activity in brain tissue that has a pH lower than normal due to pathological conditions. |