| abstract |
The present specification includes the Indy gene, polypeptides encoded by the Indy gene, and fragments thereof. The present specification also includes homologs of Indy genes derived from both Drosophila and other organisms. Furthermore, the present specification provides Indy polynucleotides, INDY proteins and polypeptides, antibodies to INDY proteins, antagonists that inhibit Indy activity or expression, and Indy activity in the treatment or diagnosis of weight loss in humans and animals or in life extension. Or use of an agonist that enhances expression. |