| abstract |
[Chemical 1] The present invention relates to novel 4-phenyl-4- [1H-imidazol-2-yl] -piperidine derivatives of formula (I), pharmaceutically acceptable acid or base addition salts thereof, stereochemical isomers thereof , Its tautomers and its N-oxide form. In particular, A = B is C═O or SO 2 , X is a covalent bond, R 1 is alkyloxy, alkyloxyalkyl, Ar or NR 9 R 10 (wherein R 9 and R 10 are each independently Or A = B and R 1 together form a benzoxazolyl group; p is 0; R 3 is optionally substituted by hydroxy, alkyl or alkyloxycarbonyl Claimed are compounds of formula (I) which are optionally benzyl and R 4 and R 5 are each hydrogen. The invention also relates to a process for the preparation of the compounds according to the invention and their use in medicine as selective non-peptide δ-opioid agonists, particularly for use in the treatment of various pain conditions. |