| abstract |
A novel gene 08P1D4 (referred to as STEAP-1) and its encoded proteins and variants are described. Although STEAP-1 exhibits tissue-specific expression in normal adult tissues, it is abnormally expressed in the cancers listed in Table I. As a result, STEAP-1 provides a diagnostic, prognostic, prophylactic and / or therapeutic target for cancer. STEAP-1 gene or fragments thereof, or their encoded proteins, or variants thereof, or fragments thereof can be used to elicit a humoral immune response or a cellular immune response; reactive to STEAP-1 The antibodies or T cells can be used in active or passive immunization. |