| abstract |
The present invention relates to a composition containing itraconazole with significantly increased bioavailability and a method for producing the same. More specifically, the present invention relates to a composition comprising itraconazole, which is a poorly soluble drug, a fatty acid or fatty acid alcohol, and a surfactant, and a method for producing the same. The composition of the present invention acts as a self-microemulsifying drug delivery system (SMEDDS), where itraconazole, a poorly soluble drug, dissolves or disperses to form a viscous phase, which is dissolved in water to form a microemulsion. Form. In order to improve the dissolution characteristics and bioavailability, the composition according to the present invention exhibits a similar medicinal effect even when a smaller amount is used than a commercial preparation such as Sporanox capsules. It is cheaper than commercial preparations such as capsules. |