| abstract |
The present invention discloses a method for modulating the enzymatic activity of prolyl endopeptidase in various human tissues and its biological effect on intracellular inositol (1,4,5) triphosphate concentration. The present invention also discloses the synergistic action of endogenous neurological and intracellular signaling cascades by the inhibitory activity of prolyl endopeptidase. The present invention further discloses the amplification of substance P-mediated stimulation of IP 3 concentrations by inhibition of proline endopeptidase activity. The effect of reduced PEP activity at the second messenger concentration indicates a new intracellular action of this peptidase that has a significant impact on recognition enhancement by PEP inhibition. Furthermore, the present invention relates to neuronal diseases such as learning and memory disorders, autoimmune diseases and T lymphocyte mediated immune diseases, and tissues such as wound healing mediated by activated fibroblasts and / or T lymphocytes. Disclose the treatment of the regeneration process. |