| abstract |
The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions containing these inhibitors and methods of using these compositions in the treatment and prevention of various disease states (eg, diabetes and Alzheimer's disease). In addition, the present invention also relates to a molecule or molecular complex containing the binding pocket of GSK-3β, or a homologue thereof. The present invention provides a computer including a data storage medium encoded with the structural coordinates of such a binding pocket. The present invention also relates to a method for elucidating the structure of homologous proteins or protein complexes using this structural coordinate. |