| abstract |
A dual inhibitor of angiotensin converting enzyme and neutral endopeptidase of formula (I) wherein R, R 1 , COOR 2 , R 3 -R 7 , alk and X have defined meanings And compounds useful as inhibitors of endothelin converting enzyme. In a preferred embodiment, R and R 5 represent hydrogen, R 1 represents benzyl, R 3 represents hydrogen, acetyl or methoxyacetyl, R 4 represents isopropyl or tert-butyl, R 6 and R 7 represent Represents methyl, X represents —O—, alk represents methylene, and COOR 2 represents carboxyl or ethoxycarbonyl. |