| abstract |
Canine, primate, porcine and fish pregnane X receptor (PXR) polynucleotides and polypeptides, and expression vectors and host cells for expression of these PXR receptors are provided. Also provided are methods for screening for modulators of these PXR receptors and methods for using these receptors for comparative pharmacology and in selecting appropriate preclinical model animals that can predict human PXR activity. Is done. |