| abstract |
A hydroxy aliphatic sulfonic acid analog represented by the following formula (I), or a pharmaceutically acceptable salt or hydrate thereof: [Chemical 1] (Where X represents an ethylene group, a vinylene group or an ethynylene group; Y represents an ethylene group, vinylene group, ethynylene group, OCH 2 or S (O) p CH 2 , where p is 0, 1 or 2; m represents an integer of 1 to 5; n represents an integer of 0 to 4; R 1 is C 1-8 alkyl group, C 3-8 cycloalkyl group, C 3-8 C 1-4 alkyl group substituted with a cycloalkyl group, ant - C 1-4 alkyl group substituted with Le group Or a C 1-4 alkyl group substituted with an aryloxy group; R 2 represents a hydrogen atom or a methyl group; R 1 and R 2 together with the carbon atom to which they are attached may form a C 3-8 cycloalkyl group; R 3 represents a hydrogen atom or a C 2-8 acyl group; R 4 represents OR 5 or NHR 6 (wherein R 5 represents a hydrogen atom, a C 1-4 alkyl group, an alkali metal, an alkaline earth metal or an ammonium group, and R 6 represents a hydrogen atom or a C 1-4 alkyl group) Show)). The compounds of the present invention are useful as elastase release inhibitors. |