| abstract |
Melanocortin receptor ligand MC-3 / MC-4 receptor ligand is disclosed. This ligand has the following formula: [Chemical 1] Where A is a conformationally restricted ring structure selected from the group consisting of: a) a non-aromatic carbocyclic ring; b) an aromatic carbocyclic ring; c) a non-aromatic heterocyclic ring; d) an aromatic heterocyclic ring; The ring contains 5 to 8 atoms, W is preferably a unit containing D-1-fluorophenylalanine, Y contains a heteroatom, and Z contains an aromatic carbocyclic ring. Also disclosed are pharmaceutical compositions comprising the ligands of the present invention and methods for treating diseases mediated by the MC-3 / MC-4 receptor. |