| abstract |
Disclosed are isolated human monoclonal antibodies and related antibody-based compositions and molecules that specifically bind to IL-15 (eg, human IL-15). The human antibodies can be produced in non-human transgenic animals such as transfectomas or transgenic mice that can produce human monoclonal antibodies of multiple isotypes by V-D-J recombination and isotype switching. Furthermore, pharmaceutical compositions containing the present human antibodies, non-human transgenic animals and hybridomas that produce the human antibodies, and therapeutic and diagnostic methods using the human antibodies are also disclosed. |