abstract |
The present invention, in one aspect, provides a two-component or bicistronic expression system based on the use of a tissue-selective promoter to drive the expression of a transcriptional activator (which then drives the gene of interest). To provide a method for selectively expressing a gene product. In another aspect, the present invention uses a tissue selective promoter (eg, hTERT or CEA), optionally combined with a binary or bicistronic expression system, to Bax, TRAIL, or various other therapies. A method for treating cancer comprising the step of expressing a protein is provided. |