| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-2468
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-2402
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-01062
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-01023
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-01108
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-2471 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-76 |
| filingDate |
2002-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2005-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2005502336-A |
| titleOfInvention |
Identification of DNA variants associated with adult lactase deficiency |
| abstract |
The present invention relates to a nucleic acid molecule comprising a 5 ′ portion of an intestinal lactase phlorizin hydrolase (LPH) gene that contributes to or represents adult lactase deficiency, comprising: (a) a sequence A nucleic acid molecule having or comprising the nucleic acid sequence of number 1, wherein the sequence of SEQ ID NO: 1 is also illustrated in FIG. 4 and also included in the sequence illustrated in FIG. 8; (b) sequence A nucleic acid molecule having or comprising the nucleic acid sequence of number 2, wherein the sequence of SEQ ID NO: 2 is also illustrated in FIG. 5 and also included in the sequence illustrated in FIG. 9; (c) A nucleic acid molecule of at least 20 nucleotides whose complementary strand hybridizes under stringent conditions with the nucleic acid molecule of (a) or (b), wherein said polynucleotide / nucleic acid molecule is located at position −13910 5 ′ from the LPH gene A nucleic acid molecule having a cytosine residue in the corresponding position; (d) a nucleic acid molecule of at least 20 nucleotides whose complementary strand hybridizes under stringent conditions with the nucleic acid molecule of (a) or (b), The polynucleotide / nucleic acid molecule relates to a nucleic acid molecule selected from the group consisting of: a nucleic acid molecule having a guanine residue at a position corresponding to position −22018 5 ′ from the LPH gene. The present invention further relates to a method for testing for the presence or predisposition of adult lactase deficiency based on the analysis of SNPs contained in the nucleic acid molecules described above. Furthermore, the present invention relates to diagnostic compositions and kits useful for detecting the presence or predisposition of adult lactase deficiency. |
| priorityDate |
2001-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |