| abstract |
The present invention relates generally to the field of psychiatry. Indeed, the present invention relates to the discovery that agents that can inhibit the binding of cortisol to its receptor can be used in methods to inhibit or reverse cognitive decline in adults with Down syndrome. Mifepristone, a potent specific glucocorticoid receptor antagonist, can be used in these methods. The invention also provides kits for inhibiting or reversing cognitive decline in DS patients, including glucocorticoid receptor antagonists, and instructional materials that teach glucocorticoid receptor antagonist indications, dosages, and administration schedules To do. |