| abstract |
Disclosed are amine derivatives, tautomeric and / or stereoisomeric forms thereof, or salts thereof having antagonistic activity of vanilloid receptor 1 (VR1). Amine derivatives have excellent activity as VR1 antagonists and for the prevention and treatment of diseases associated with VRI activity, in particular urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, Useful for the treatment of rheumatoid arthritis pain, neuralgia, neuropathy, hyperalgesia, nerve injury, ischemia, neurodegeneration, stroke, incontinence and / or inflammatory disorders. |