http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2005501819-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-443 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- |
| filingDate | 2002-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2005501819-A |
| titleOfInvention | Paroxetine hydrochloride preparation process limiting the formation of pink compounds |
| abstract | Provided is a method for preparing paroxetine hydrochloride from a paroxetine base that provides paroxetine hydrochloride substantially free of impurities identified as about 1.5 by the pink compound of the present invention or HPLC RRT. The method of the present invention utilizes crystallization / recrystallization in the presence of buffer, less than 1 HCl to paroxetine base molar ratio, and an effective amount of an antioxidant. A preferred means of creating a buffer is by the use of ammonium chloride. A preferred antioxidant is ascorbic acid. The present invention further provides recrystallizable paroxetine hydrochloride prepared by the above method or any other method in the presence of an effective amount of an antioxidant, such as ascorbic acid. A suitable solvent system for recrystallization is a mixture of acetone and methanol. The method of the present invention may combine these various features. |
| priorityDate | 2001-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.