| abstract |
According to the present invention, there is provided a method for identifying a regulator of voltage-gated sodium channel (VGSC), wherein said VGSC, p11 peptide, and test are under conditions that allow VGSC and p11 peptide to form a complex without a test compound. A step of contacting the compound and a step of measuring the activity of the VGSC, wherein a change in the activity of the VGSC relative to the activity without the test compound is used as an indicator that the test compound is an indicator of the VGSC A method is provided. The compounds identified by such screening methods are recommended for use in the treatment or prevention of conditions associated with VGSC, such as pain. Also provided is a method of increasing the functional expression of voltage-gated sodium channels (VGSCs) in a cell, comprising increasing the p11 level in the cell. |