| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-32213
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00166
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-3221
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J19-242
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01F25-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01F25-43141
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J19-32 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01F5-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01F5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J19-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J19-32 |
| filingDate |
2002-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2005-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2005500350-A |
| titleOfInvention |
Process for producing amino-protected derivatives of 4-aminomethylene-pyrrolidin-3-one and / or 4-aminomethylene-pyrrolidine-3-alkoxyimino derivatives and / or gemifloxacin or a salt thereof |
| abstract |
The present invention is a process for producing a compound of the following formula (I) (wherein P 1 and P 2 are amino protecting groups, which may be the same or different) in a solution phase continuous operation mode, The manufacturing method including the process of protecting the compound of (II) is provided. This provides advantages over batch mode operation. This process is usually performed using a reactor that is adapted for use in a continuous mode of operation. Preferably, the plug flow reactor comprises a jacketed tubular reactor in which is fixed an internal mixing element that continuously splits and remixes the reaction stream to facilitate mass transfer and heat transfer, thereby allowing fluid flow. To achieve a uniform plug flow profile with turbulent flow. The present invention also provides a method for producing the antibacterial compound gemifloxacin, or a pharmaceutically acceptable salt and / or hydrate thereof, the method comprising the step of converting the compound of formula (I). provide. The present invention also provides a method for producing a compound of the following formula (VIIIa). |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010024123-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009142806-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8551417-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020217393-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8210397-B2 |
| priorityDate |
2001-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |