| abstract |
Receptor protein tyrosine kinase (fibroblast growth factor receptor 3 ( Molecules have been found that contain the antigen-binding portion of an antibody that blocks constitutive and / or ligand-dependent activation of FGFR3). Molecules of the invention that block constitutive activation treat or inhibit skeletal dysplasia, skull fusion, cell proliferative diseases or disorders, or tumor progression associated with constitutive activation of receptor protein tyrosine kinases Can be administered. |