http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2005318892-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d75d1a4caed60a9316608ed9c231546c |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| filingDate | 2005-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_307b61b1f8de9be546834f228f75203c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82bc5155600c422b8de7607e80a30dd4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c810b1dedd0ef9696dde5e7eaf6a626 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fcdbdd1b2a980bd02efc802d1ab5d33c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cdccde833eeb5b9b7944737fd2533e1d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d7ec0772c2bb87cd6cdda8063cc4947 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b08e647f5a04637ed00a6f5716f7d78c |
| publicationDate | 2005-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2005318892-A |
| titleOfInvention | Non-human diabetes model animal |
| abstract | PROBLEM TO BE SOLVED: To provide a model animal for diabetes such as juvenile-onset adult type diabetes and permanent neonatal diabetes. The present invention provides a non-human mammal having a glucokinase gene having a base substitution of any one of (A) and (B) below. (A) Substitution of the first guanine of the intron immediately after exon 1A, the third cytosine from the 3 ′ side of the intron immediately before exon 3 and the second thymine of the intron immediately after exon 8 to the other thymine, (B) The amino acid sequence of the protein encoded by the glucokinase gene is 224th methionine as arginine, 220th cysteine as tyrosine, 182nd valine as methionine, 273th tyrosine and 345th arginine throughout Replace 228 with threonine, 419 with phenylalanine, leucine, 206 with threonine, and 127 with serine. [Selection] Figure 1 |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4036242-A4 |
| priorityDate | 2004-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 322.