| abstract |
PROBLEM TO BE SOLVED: To provide a vaccine composition effective against HCV comprising a safe and non-toxic adjuvant. An HCV E1E2 composition comprising an E1E2 antigen, a submicron oil-in-water emulsion and / or an immunostimulatory nucleic acid sequence is disclosed. The composition can be used in a method of stimulating an immune response in a vertebrate subject. The present invention relates to submicron oil-in-water emulsions and immunostimulatory nucleic acid sequences (ISS) (eg, CpY motif, CpR motif, and unmethylated CpG motif (cytosine followed by guanosine and linked by phosphate bonds). The surprising discovery that the use of HCV E1E2 antigen in combination with oligonucleotides containing) provides significantly higher immune titers than those observed in the absence of such adjuvants Partly depends. [Selection figure] None |