| abstract |
The present invention provides novel heavy chain antibodies and single domain heavy chain antibody fragments useful in the field of immunology. According to Kabat numbering, a 45-position amino acid that is neither a charged amino acid nor a cysteine is selected from the group consisting of R, G, K, S, and P at position 103, optionally in combination with Q at position 108 A functional heavy chain antibody comprising an amino acid. [Selection figure] None |