| abstract |
PROBLEM TO BE SOLVED: To provide a method for inducing CTL (cytotoxic T lymphocyte) functioning specifically for a disease antigen, which can be used for treatment of difficult diseases such as cancer and viral infection. To do. In order to achieve the above object, the method for inducing CTLs of the present invention uses a cell line expressing at least a major histocompatibility antigen (MHC) class I and a co-stimulatory molecule as a disease. It is an induction method characterized by co-culturing with lymphocytes after or while contacting with an antigenic peptide. CTL induced by the method of the present invention is useful for, for example, drugs for cancer and infectious diseases, and methods for treating and preventing them. Moreover, according to the induction method of the present invention, the potential proliferation ability of CTL can be examined. [Selection figure] None |