| abstract |
Disclosed is a substance having affinity for an opioid δ receptor, a pharmaceutical useful for the prevention and / or treatment of central nervous system diseases and peripheral nervous system diseases. The following general formula (I) [Chemical 1] [Wherein, X represents O, S, N, etc .; n represents 0, 1, 2; broken line portion represents presence or absence of bonding; R 1 and R 3 each independently represent a hydrogen atom, a halogen atom, hydroxy A group, an optionally substituted lower alkyl group, and the like; R 2 and R 4 each independently represents a hydrogen atom, an optionally substituted lower alkyl group, and the like. Or a pharmacologically acceptable salt thereof as an active ingredient. |