| abstract |
The present invention provides compounds useful as PDE IV and TNF inhibitors. SOLUTION: Formula [Wherein R 1 is alkyl; R 2 is alkyl, alkenyl or alkynyl, cycloalkyl or cycloalkenyl, or cyclothioalkyl in which at least one of the ring atoms is sulfur and the other ring atom is carbon, Or cyclothioalkenyl; R 3 is aryl or heteroaryl; Q 1 , Q 2 and Q 3 are independently nitrogen, CX or CH provided that at least one of Q 1 , Q 2 and Q 3 Z is other than CH; Z, Z 1 and Z 2 are independently oxygen or sulfur; Z 3 is —CH═CH—, —CZCH 2 —, —CZ—CZ—, —CH 2 —NH—. , -CH 2 -O -, - CX 2 -O -, - CH 2 -S -, - CH 2 -SO 2 - or a -CZNH-; and X the compounds of is halo or Its N-oxide or pharmaceutically acceptable salt. [Selection figure] None |