| abstract |
Disclosed is a compound that suppresses infiltration of leukocytes such as eosinophils and lymphocytes and is effective as a therapeutic agent for various inflammations. A 5-membered ring compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof. [R 1 represents a hydrogen atom, alkyl, aryl, or heteroaryl. R 2 represents a hydrogen atom, alkyl, aryl, heteroaryl, or —CON (R 6 ) R 7 . Y 1 represents a single bond, optionally substituted alkylene, -CO (CH 2) n - , - SO 2 (CH 2) n -, - CONH (CH 2) n -, - CSNH (CH 2) n -, or -COO (CH 2) n - represents a. n represents an integer of 0 to 5. The wavy line means (E) or (Z) coordination. R 3 represents a hydrogen atom, aryl, heteroaryl, or cycloalkyl. Y 2 represents alkylene, alkenylene, or the like. R 4 represents imidazol-4-yl, benzimidazol-2-yl, 1,2,3-triazol-4-yl, 1,2,4-triazol-3-yl. ] [Selection figure] None |