| abstract |
PROBLEM TO BE SOLVED: To provide a preparation which prevents elution by gastric juice and enhances bioavailability in a calcium L-threonate preparation. SOLUTION: A composition for oral administration containing calcium L-threonate contains a hydroxycarboxylic acid other than L-threonic acid and L-ascorbic acid. The hydroxycarboxylic acid is preferably citric acid, lactic acid or malic acid. The hydroxycarboxylic acid content is preferably 0.1 to 10% by mass with respect to calcium L-threonate. The dosage form is preferably a tablet. The tablet is preferably coated with an enteric coating. The enteric coating agent is preferably selected from gelatin, shellac, zein, ethyl cellulose and methacrylic acid copolymer. [Selection figure] None |