| abstract |
PROBLEM TO BE SOLVED: To provide a medicinal effect evaluation system reflecting inflammatory bowel disease (IBD) accompanied by fibrosis and a drug useful for improving the disease. An IL-1 antagonist, an anti-IL-1 antibody, an inhibitor of IL-1 gene expression, or an inhibitor of IL-1 protein expression or function (activity) is used to treat IBD diseases associated with fibrosis. Used as a therapeutic agent. [Selection figure] None |