| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_675890b893066a28f59cbf5b8aa780c5 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01R33-62 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01R33-465 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01R33-62 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N24-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01R33-465
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01R33-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01R33-32 |
| filingDate |
2004-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba967e65d38d2a54aa191cc8da35f34c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6625ddcaec921c4c5cebc7131a1e8260 |
| publicationDate |
2005-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2005181332-A |
| titleOfInvention |
Method |
| abstract |
The present invention is a method for characterizing the metabolic stability of a drug candidate, wherein the nuclear polarization of an NMR active nuclide present in the drug candidate is increased (hereinafter referred to as “hyperpolarization”), and the drug candidate is defined as a hepatocyte. Or it relates to a method comprising contacting with an organelle and performing NMR analysis. [Effect] This method is a rapid and simple in vitro assay and is particularly suitable for screening a large number of drug candidates. The methods of the present invention do not require isolation of drug candidates and / or their metabolites from the assay material. Since the hyperpolarized drug candidate is used in the method of the present invention, the sensitivity is superior to that of a normal NMR assay, and therefore, a very small amount of metabolites that cannot be detected by conventional NMR can be detected. [Selection figure] None |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009514946-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9606106-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009063487-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015509584-A |
| priorityDate |
2003-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |